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I would say the way a shoes fits is a very important issue: it is not the same having a wide foot than a narrow one; your foot can be wider in the midfoot and not that much in the toes...and so on.
I think fitting is a very important question; for me it has been the main reason for choice so far.
Heel to toe offset maybe another factor to take into acount, since it influences the way you contact the ground. There has to be a particular offset you like the most after trying some of them.
Flexibility is something to consider as well: you must determine wether you prefer flexible shoes or rather stiff ones.